Key Publications

(2022) Evans RJ, Perkins DW, Selfe J, Kelsey A, Birch GB, Shipley JM, Schipper K, Isacke CM. Endo180 (MRC2) Antibody-Drug Conjugate for the Treatment of Sarcoma. Mol Cancer Ther. 2023 Feb 1;22(2):240-253. doi: 10.1158/1535-7163.MCT-22-0312. PMID: 36399638. PMCID: PMC9890142.

(2021) Çakılkaya P, Sørensen RR, Jürgensen HJ, Krigslund O, Gårdsvoll H, Nielsen CF, Santoni-Rugiu E, Behrendt N, Engelholm LH. The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target. Int J Mol Sci. 2021 Oct 23;22(21):11452. doi: 10.3390/ijms222111452. PMID: 34768883; PMCID: PMC8583732.

(2017) Nielsen CF, van Putten SM, Lund IK, Melander MC, Nørregaard KS, Jürgensen HJ, Reckzeh K, Christensen KR, Ingvarsen SZ, Gårdsvoll H, Jensen KE, Hamerlik P, Engelholm LH, Behrendt N. The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers. Oncotarget. 2017 Jul 4;8(27):44605-44624. doi: 10.18632/oncotarget.17883. PMID: 28574834; PMCID: PMC5546505.

(2016) Engelholm LH, Melander MC, Hald A, Persson M, Madsen DH, Jürgensen HJ, Johansson K, Nielsen C, Nørregaard KS, Ingvarsen SZ, Kjaer A, Trovik CS, Laerum OD, Bugge TH, Eide J, Behrendt N. Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180. J Pathol. 2016 Jan;238(1):120-33. doi: 10.1002/path.4661. Epub 2015 Nov 30. PMID: 26466547.

(2015) Melander MC, Jürgensen HJ, Madsen DH, Engelholm LH, Behrendt N. The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review). Int J Oncol. 2015 Oct;47(4):1177-88. doi: 10.3892/ijo.2015.3120. Epub 2015 Aug 12. PMID: 26316068; PMCID: PMC4583827.

(2014) Jürgensen HJ, Johansson K, Madsen DH, Porse A, Melander MC, Sørensen KR, Nielsen C, Bugge TH, Behrendt N, Engelholm LH. Complex determinants in specific members of the mannose receptor family govern collagen endocytosis. J Biol Chem. 2014 Mar 14;289(11):7935-47. doi: 10.1074/jbc.M113.512780. Epub 2014 Feb 5. PMID: 24500714; PMCID: PMC3953304.

(2011) Jürgensen HJ, Madsen DH, Ingvarsen S, Melander MC, Gårdsvoll H, Patthy L, Engelholm LH, Behrendt N. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180. J Biol Chem. 2011 Sep 16;286(37):32736-48. doi: 10.1074/jbc.M111.266692. Epub 2011 Jul 18. PMID: 21768090; PMCID: PMC3173195.

(2011) Madsen DH, Ingvarsen S, Jürgensen HJ, Melander MC, Kjøller L, Moyer A, Honoré C, Madsen CA, Garred P, Burgdorf S, Bugge TH, Behrendt N, Engelholm LH. The non-phagocytic route of collagen uptake: a distinct degradation pathway. J Biol Chem. 2011 Jul 29;286(30):26996-7010. doi: 10.1074/jbc.M110.208033. Epub 2011 Jun 7. PMID: 21652704; PMCID: PMC3143658.

(2010) Huijbers IJ, Iravani M, Popov S, Robertson D, Al-Sarraj S, Jones C, Isacke CM. A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. PLoS One. 2010 Mar 22;5(3):e9808. doi: 10.1371/journal.pone.0009808. PMID: 20339555; PMCID: PMC2842440.

(2009) Engelholm LH, Ingvarsen S, Jürgensen HJ, Hillig T, Madsen DH, Nielsen BS, Behrendt N. The collagen receptor uPARAP/Endo180. Front Biosci (Landmark Ed). 2009 Jan 1;14(6):2103-14. doi: 10.2741/3365. PMID: 19273187.

(2007) Madsen DH, Engelholm LH, Ingvarsen S, Hillig T, Wagenaar-Miller RA, Kjøller L, Gårdsvoll H, Høyer-Hansen G, Holmbeck K, Bugge TH, Behrendt N. Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation. J Biol Chem. 2007 Sep 14;282(37):27037-27045. doi: 10.1074/jbc.M701088200. Epub 2007 Jul 9. PMID: 17623673.

(2007) Sulek J, Wagenaar-Miller RA, Shireman J, Molinolo A, Madsen DH, Engelholm LH, Behrendt N, Bugge TH. Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer. J Histochem Cytochem. 2007 Apr;55(4):347-53. doi: 10.1369/jhc.6A7133.2006. Epub 2006 Dec 22. PMID: 17189524.

(2005) Curino AC, Engelholm LH, Yamada SS, Holmbeck K, Lund LR, Molinolo AA, Behrendt N, Nielsen BS, Bugge TH. Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol. 2005 Jun 20;169(6):977-85. doi: 10.1083/jcb.200411153. PMID: 15967816; PMCID: PMC2171632.

(2005) Thomas EK, Nakamura M, Wienke D, Isacke CM, Pozzi A, Liang P. Endo180 binds to the C-terminal region of type I collagen. J Biol Chem. 2005 Jun 17;280(24):22596-605. doi: 10.1074/jbc.M501155200. Epub 2005 Apr 6. PMID: 15817460.

(2004) Kjøller L, Engelholm LH, Høyer-Hansen M, Danø K, Bugge TH, Behrendt N. uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV. Exp Cell Res. 2004 Feb 1;293(1):106-16. doi: 10.1016/j.yexcr.2003.10.008. PMID: 14729061.

(2003) Engelholm LH, List K, Netzel-Arnett S, Cukierman E, Mitola DJ, Aaronson H, Kjøller L, Larsen JK, Yamada KM, Strickland DK, Holmbeck K, Danø K, Birkedal-Hansen H, Behrendt N, Bugge TH. uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol. 2003 Mar 31;160(7):1009-15. doi: 10.1083/jcb.200211091. PMID: 12668656; PMCID: PMC2172772.

(2002) Schnack Nielsen B, Rank F, Engelholm LH, Holm A, Danø K, Behrendt N. Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells. Int J Cancer. 2002 Apr 10;98(5):656-64. doi: 10.1002/ijc.10227. PMID: 11920633.

(2000) Behrendt N, Jensen ON, Engelholm LH, Mørtz E, Mann M, Danø K. A urokinase receptor-associated protein with specific collagen binding properties. J Biol Chem. 2000 Jan 21;275(3):1993-2002. doi: 10.1074/jbc.275.3.1993. PMID: 10636902.

(1990) Isacke CM, van der Geer P, Hunter T, Trowbridge IS. p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. Mol Cell Biol. 1990 Jun;10(6):2606-18. doi: 10.1128/mcb.10.6.2606-2618.1990. PMID: 2188094; PMCID: PMC360619.